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Glucocorticoid Receptor antibody [GT1073]

Anti-Glucocorticoid Receptor antibody [GT1073] used in IHC (Paraffin sections) (IHC-P). GTX634705
Anti-Glucocorticoid Receptor antibody [GT1073] used in IHC (Paraffin sections) (IHC-P). GTX634705
Anti-Glucocorticoid Receptor antibody [GT1073] used in Western Blot (WB). GTX634705

Cat. No. GTX634705

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 GT1073

Isotype

 IgG2a

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399),
25 μl ($169)
See all Glucocorticoid Receptor products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

86 kDa. ( Note )

Positive Control

A431 , HeLa , HepG2

Predict Reactivity

Sheep, Bovine, Cat, Dog, Guinea pig, Pig(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

2.21 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the N-terminus region of human Glucocorticoid receptor. The exact sequence is proprietary.

Purification

Affinity purified by Protein A.

Conjugation

Unconjugated

RRID

AB_2888473

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

nuclear receptor subfamily 3 group C member 1 , GCCR , GCR , GCRST , GR , GRL

Cellular Localization

Nucleus,Mitochondrion,Cytoplasm

Background

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

Database

Research Area

DATA IMAGES

Anti-Glucocorticoid Receptor antibody [GT1073] used in IHC (Paraffin sections) (IHC-P). GTX634705

GTX634705 IHC-P Image

Glucocorticoid Receptor antibody [GT1073] detects Glucocorticoid Receptor protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded mouse intestine.
Glucocorticoid Receptor stained by Glucocorticoid Receptor antibody [GT1073] (GTX634705) diluted at 1:1000.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-Glucocorticoid Receptor antibody [GT1073] used in IHC (Paraffin sections) (IHC-P). GTX634705

GTX634705 IHC-P Image

Glucocorticoid Receptor antibody [GT1073] detects Glucocorticoid Receptor protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded rat brain.
Glucocorticoid Receptor stained by Glucocorticoid Receptor antibody [GT1073] (GTX634705) diluted at 1:1000.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-Glucocorticoid Receptor antibody [GT1073] used in Western Blot (WB). GTX634705

GTX634705 WB Image

Various whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with Glucocorticoid Receptor antibody [GT1073] (GTX634705) diluted at 1:1000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399
$ 169
Custom Conjugations