GeneTex
United States (US)

Glucocorticoid Receptor beta antibody

GTX16319_2071_WB_19011519_112.jpg

Cat No. GTX16319

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF, FACS, IP, GSA, IHC
Reactivity Human, Sheep, Pig
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500
ICC/IF 1:1,500
FACS Assay dependent
IP Assay dependent
GSA Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

86 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Serum diluted in PBS, 0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Synthetic Peptide: N(728) V M W L K P E S T S H T L I(742) C

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Nuclear Receptor Subfamily 3 Group C Member 1,Gccr,Gcr,Gcrst,Gr,Grl,Nr3C1

Cellular Localization

Centrosome,Cytoplasm,Cytoskeleton,Microtubule organizing center,Mitochondrion,Nucleus,Spindle

Background

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

Database

Research Area

DATA IMAGES
GTX16319_2071_WB_19011519_112.jpg

GTX16319 WB Image

WB analysis of hGR beta transfected COS-74 whole cell extract using GTX16319 Glucocorticoid Receptor beta antibody.

Package List Price ($)
$ 319