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Glypican-3 antibody [1G12]

Cat. No. GTX01702

Reference 5

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 1G12

Isotype

 IgG1

Application

 WB, IHC-P, FACS, IP

Reactivity

 Human
Package
500 μl ($399)
See all Glypican-3 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-P 1:100-1:200
FACS Assay dependent
IP Assay dependent

Note :

IHC-P
Pretreatment of deparaffinized tissue with heat-induced epitope retrieval or enzymatic retrieval is recommended.
Not tested in other applications.

Calculated MW

66 kDa. ( Note )

Positive Control

Prostate intraepithelial neoplasia (PIN)

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant diluted in Tris-HCl buffer, 0.2% BSA

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Antigen Species

Human

Immunogen

A fragment containing the last 70 amino acids of human core glypican-3 protein

Purification

unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

glypican 3 , DGSX , GTR2-2 , MXR7 , OCI-5 , SDYS , SGB , SGBS , SGBS1

Cellular Localization

Cell membrane

Background

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Database

Research Area

REFERENCE

Clone Reference

2020; Colorectal adenocarcinoma with enteroblastic differentiation: a clinicopathological study of five cases
Application : IHC-P
2019; Glypican-3 and Hep Par-1 are Useful Biomarkers in the Cytologic Assessment of Ascites
Application : IHC-P
Reactivity : Human
2017; Heparan sulfate proteoglycans (HSPGs) and chondroitin sulfate proteoglycans (CSPGs) function as endocytic receptors for an internalizing anti-nucleic acid antibody
Application : FACS, IP
Reactivity : Human
2013; Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinoma
Application : WB
Reactivity : Human
2013; Diagnostic value of glypican-3 in alpha fetoprotein negative hepatocellular carcinoma patients
Application : IHC-P
Reactivity : Human
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Package List Price ($)
$ 399