Gremlin 1 antibody

Cat. No. GTX03394

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	IHC-P
Reactivity	Human
Package	100 μl ($399)

See all Gremlin 1 products

Datasheet

View product citations for antibody GTX03394 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
IHC-P	1:200-1:400

Not tested in other applications.

Calculated MW

21 kDa. ( Note )

Predict Reactivity

Rabbit, Bovine, Dog, Chicken, Horse(>80% identity)

PROPERTIES

Form

Liquid

Buffer

Aqueous buffered solution, 1% BSA, 50% glycerol

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide derived from human gremlin 1 (101-184).

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

gremlin 1, DAN family BMP antagonist , C15DUPq , CKTSF1B1 , CRAC1 , CRCS4 , DAND2 , DRM , DUP15q , GREMLIN , HMPS , HMPS1 , IHG-2 , MPSH , PIG2

Cellular Localization

Secreted

Background

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Database

Gene ID: 26585 GREM1
UniProt: O60565 GREM1

Research Area

DATA IMAGES

GTX03394 IHC-P Image

IHC-P analysis of human aortic tissue sections using GTX03394 Gremlin 1 antibody.
Dilution : 1:200

REFERENCE

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REVIEW

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Package

List Price ($)

100 μl

$ 399

Qty