APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:200-1:400 |
Not tested in other applications.
Predict Reactivity
Rabbit, Bovine, Dog, Chicken, Horse(>80% identity)
PROPERTIES
Form
Liquid
Buffer
Aqueous buffered solution, 1% BSA, 50% glycerol
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
KLH conjugated synthetic peptide derived from human gremlin 1 (101-184).
Purification
Protein A purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
gremlin 1, DAN family BMP antagonist , C15DUPq , CKTSF1B1 , CRAC1 , CRCS4 , DAND2 , DRM , DUP15q , GREMLIN , HMPS , HMPS1 , IHG-2 , MPSH , PIG2
Cellular Localization
Secreted
Background
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Database
Research Area
DATA IMAGES
|
GTX03394 IHC-P Image
IHC-P analysis of human aortic tissue sections using GTX03394 Gremlin 1 antibody.
Dilution : 1:200
|
REFERENCE
REVIEW
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