Gremlin 1 antibody

Cat. No. GTX03707

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC-P
Reactivity	Human, Mouse
Package	400 μl ($399)

See all Gremlin 1 products

Datasheet

View product citations for antibody GTX03707 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1:2000
IHC-P	1:50-1:100

Not tested in other applications.

Calculated MW

21 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

KLH conjugated synthetic peptide between 147-175 amino acids from the C-terminal region of mouse GREMLIN.

Purification

Protein A purified followed by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

gremlin 1, DAN family BMP antagonist , Cktsf1b1 , Drm , Grem , ld

Cellular Localization

Secreted

Background

Enables receptor ligand activity; transmembrane receptor protein tyrosine kinase activator activity; and vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including cell migration involved in sprouting angiogenesis; nephron epithelium morphogenesis; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of branching involved in ureteric bud morphogenesis; and regulation of signal transduction. Located in extracellular space. Colocalizes with cell surface. Is expressed in several structures, including embryo mesenchyme; limb bud; neural ectoderm; sensory organ; and skeleton. Orthologous to human GREM1 (gremlin 1, DAN family BMP antagonist). [provided by Alliance of Genome Resources, Apr 2022]

Database

Gene ID: 23892 Grem1
UniProt: O70326 Grem1

Research Area

DATA IMAGES

GTX03707 IHC-P Image

IHC-P analysis of human skeletal muscle tissue GTX03707 Gremlin 1 antibody.

GTX03707 IHC-P Image

IHC-P analysis of human spleen tissue GTX03707 Gremlin 1 antibody.
Dilution : 1:400

GTX03707 WB Image

WB analysis of mouse skeletal muscle lysate using GTX03707 Gremlin 1 antibody.
Dilution : 1:2000
Loading : 20 μg per lane

GTX03707 IHC-P Image

IHC-P analysis of mouse kidney tissue GTX03707 Gremlin 1 antibody.
Dilution : 1:200

GTX03707 IHC-P Image

IHC-P analysis of mouse spleen tissue GTX03707 Gremlin 1 antibody.
Dilution : 1:200

GTX03707 IHC-P Image

IHC-P analysis of human renal tissue GTX03707 Gremlin 1 antibody.
Antigen retireval : Heat induced epitope retrieval Citrate buffer pH 6.0 in microwave
Dilution : 1:50

GTX03707 IHC-P Image

IHC-P analysis of mouse lung tissue GTX03707 Gremlin 1 antibody.
Dilution : 1:200

GTX03707 IHC-P Image

IHC-P analysis of crescentic PECs and tubular epithelial cells of patients with pauci-immune GN using GTX03707 Gremlin 1 antibody. In comparison with normal renal tissue in which there is no expression of gremlin mRNA (C), proliferating PECs of glomerular crescents show a strong expression of gremlin mRNA by ISH (A); and gremlin protein expression by IMH (B); immune competent infiltrating interstitial cells are also strongly positive for gremlin staining (E); and CTGF was also expressed in these glomerular crescentic cells (F).

GTX03707 IHC-P Image

IHC-P analysis of human spleen tissue GTX03707 Gremlin 1 antibody.
Dilution : 1:200

GTX03707 IHC-P Image

IHC-P analysis of mouse kidney tissue GTX03707 Gremlin 1 antibody.
Dilution : 1:400

GTX03707 IHC-P Image

IHC-P analysis of mouse spleen tissue GTX03707 Gremlin 1 antibody.
Dilution : 1:400

GTX03707 IHC-P Image

IHC-P analysis of mouse lung tissue GTX03707 Gremlin 1 antibody.
Dilution : 1:400

REFERENCE

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REVIEW

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Package

List Price ($)

400 μl

$ 399

Qty

Gremlin 1 antibody

Cat. No. GTX03707

Host

Clonality

Isotype

Application

Reactivity

APPLICATION

Application Note

Calculated MW

PROPERTIES

Form

Buffer

Preservative

Storage

Concentration

Antigen Species

Immunogen

Purification

Conjugation

Note

TARGET

Synonyms

Cellular Localization

Background

Database

Research Area

DATA IMAGES

GTX03707 IHC-P Image

GTX03707 IHC-P Image

GTX03707 WB Image

GTX03707 IHC-P Image

GTX03707 IHC-P Image

GTX03707 IHC-P Image

GTX03707 IHC-P Image

GTX03707 IHC-P Image

GTX03707 IHC-P Image

GTX03707 IHC-P Image

GTX03707 IHC-P Image

GTX03707 IHC-P Image

REFERENCE

REVIEW

Product

Research

Support

Company

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