GeneTex

  • Country / Location Selection

United States (US)

HAAO antibody

Anti-HAAO antibody used in IHC (Paraffin sections) (IHC-P). GTX85015
Anti-HAAO antibody used in IHC (Paraffin sections) (IHC-P). GTX85015
Anti-HAAO antibody used in Western Blot (WB). GTX85015

Cat. No. GTX85015

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all HAAO products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

33 kDa. ( Note )

Positive Control

Mouse Liver Tissue Lysate(GTX27935) , Human Liver Tissue Slide

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

HAAO antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human HAAO.The immunogen is located within amino acids 30 - 80 of HAAO.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

3-hydroxyanthranilate 3,4-dioxygenase , 3-HAO , HAO , VCRL1 , h3HAO

Cellular Localization

Cytoplasm, cytosol

Background

HAAO (3-Hydroxyanthranilate 3,4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer.

Database

Research Area

DATA IMAGES

Anti-HAAO antibody used in IHC (Paraffin sections) (IHC-P). GTX85015

GTX85015 IHC-P Image

IHC-P analysis of human liver tissue using GTX85015 HAAO antibody.
Working concentration : 2.5 μg/ml

Anti-HAAO antibody used in IHC (Paraffin sections) (IHC-P). GTX85015

GTX85015 IHC-P Image

IHC-P analysis of human liver tissue using GTX85015 HAAO antibody.
Working concentration : 20 μg/ml

Anti-HAAO antibody used in Western Blot (WB). GTX85015

GTX85015 WB Image

WB analysis of mouse liver tissue lysate using GTX85015 HAAO antibody.
Working concentration : 1 μg/ml

REFERENCE

There are currently no references for HAAO antibody (GTX85015). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for HAAO antibody (GTX85015). Be the first to share your experience with this product.
Submit a Review
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399