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HDAC8 antibody

KO/KD
Anti-HDAC8 antibody used in Western Blot (WB). GTX57746
Anti-HDAC8 antibody used in IHC (Paraffin sections) (IHC-P). GTX57746
Anti-HDAC8 antibody used in IHC (Paraffin sections) (IHC-P). GTX57746
Anti-HDAC8 antibody used in IHC (Paraffin sections) (IHC-P). GTX57746
Anti-HDAC8 antibody used in Western Blot (WB). GTX57746

Cat. No. GTX57746

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($409)
See all HDAC8 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

42 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-377 of human HDAC8 (NP_060956.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

histone deacetylase 8 , CDA07 , CDLS5 , HD8 , HDACL1 , KDAC8 , MRXS6 , RPD3 , WTS

Cellular Localization

Nucleus,Cytoplasm

Background

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Database

Research Area

DATA IMAGES

Anti-HDAC8 antibody used in Western Blot (WB). GTX57746

GTX57746 WB Image

KO/KD

WB analysis of normal (control) and knockout (KO) HeLa cell lysate using GTX57746 HDAC8 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-HDAC8 antibody used in IHC (Paraffin sections) (IHC-P). GTX57746

GTX57746 IHC-P Image

IHC-P analysis of rat spinal cord tissue using GTX57746 HDAC8 antibody.
Dilution : 1:100

Anti-HDAC8 antibody used in IHC (Paraffin sections) (IHC-P). GTX57746

GTX57746 IHC-P Image

IHC-P analysis of human breast cancer tissue using GTX57746 HDAC8 antibody.
Dilution : 1:100

Anti-HDAC8 antibody used in IHC (Paraffin sections) (IHC-P). GTX57746

GTX57746 IHC-P Image

IHC-P analysis of rat testis tissue using GTX57746 HDAC8 antibody.
Dilution : 1:100

Anti-HDAC8 antibody used in Western Blot (WB). GTX57746

GTX57746 WB Image

WB analysis of various sample lysates using GTX57746 HDAC8 antibody.
Dilution : 1:1000
Loading : 25μg per lane

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 409