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HEF1 antibody [14A11]

Cat. No. GTX18059

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 14A11

Isotype

 IgG2b

Application

 ICC/IF, IP

Reactivity

 Human
Package
50 μl ($399)
See all HEF1 products

APPLICATION

Application Note

Recommended Starting Dilutions:
at 1μg of antibody per 200μg of whole cell lysate for IP, & 1:100 for IF
Optimal dilutions should be determined experimentally by the researcher.

Calculated MW

93 kDa. ( Note )

Product Note

Specific for human HEF1 localized in mitotic cells in the spindle and the centrosome. It does not recognize p130Cas. Have not tested it on Sin1

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Immunogen

GST-HEF-1 (82-398aa.)

Purification

Protein G

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

neural precursor cell expressed, developmentally down-regulated 9 , CAS-L , CAS2 , CASL , CASS2 , HEF1

Cellular Localization

Nucleus , Golgi apparatus , Cytoplasm

Background

The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399