HICE1 antibody recognizes HICE1 protein encoded by the human HAUS8 gene. HICE1 is a subunit of the microtubule-associated HAUS augmin-like complex, which is involved in maintenance of spindle integrity and microtubule nucleation during spindle assembly. Disruption of HICE1 results in abnormal spindle configuration, mitotic delay, and chromosomal instability.
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
0.17 mg/ml (Please refer to the vial label for the specific concentration.)
Recombinant protein corresponding to human HICE1
Purified by antigen-affinity chromatography.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
HAUS augmin like complex subunit 8 , DGT4 , HICE1 , NY-SAR-48
Cytoplasm , Centrosome , Spindle
HAUS8 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM]