GeneTex
United States (US)

HIRA antibody

HIRA-antibody-GTX87684-IHC-1_18121411_954.jpg

Cat No. GTX87684

Host Rabbit
Clonality Polyclonal
Application IHC-P, ELISA
Reactivity Human, Mouse
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

111 kDa. ( Note )

Specificity/Sensitivity

HIRA (Ab-555) Antibody detects endogenous levels of total HIRA protein.
PROPERTIES

Form

Liquid

Buffer

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized peptide derived from human HIRA.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

TUPLE1, HIRA, TUP1 like enhancer of split protein1, DGCR1, TUP1 like enhancer of split protein 1

Cellular Localization

Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.

Background

Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
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Database

DATA IMAGES
HIRA-antibody-GTX87684-IHC-1_18121411_954.jpg

GTX87684 IHC-P Image

Immunohistochemistry analysis of paraffin-embedded human tonsil tissue, using HIRA (Ab-555) Antibody. The picture on the right is treated with the synthesized peptide.

Package List Price ($)
$ 339