HLA-A2 antibody [BB7.2] (PE)

Cat No. GTX75805

Host	Mouse
Clonality	Monoclonal
Clone Name	BB7.2
Isotype	IgG2b
Application	FACS
Reactivity	Human
Package	50 test ($319)

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Datasheet
Document

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
FACS	Neat
Note : FACS Use 10μl of the suggested working dilution to label 10⁶ cells or 100μl whole blood.

Not tested in other applications.

Calculated MW

41 kDa. ( Note )

Specificity/Sensitivity

The epitope recognized by this antibody has been studied extensively and would appear to include the carboxy-terminus of the alpha-2 helix and a turn on one of the underlying beta strands.

PROPERTIES

Form

Liquid

Buffer

PBS, 0.09% Sodium Azide, 1% BSA, 5% Sucrose

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Papain solubilised HLA-A2

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Phycoerythrin (PE)

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Major Histocompatibility Complex, Class I, A , Hlaa , Hla-A

Background

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]

Research Area

DATA IMAGES

GTX75805 FACS Image

FACS analysis of human peripheral blood lymphocytes using GTX75805 HLA-A2 antibody [BB7.2] (PE).

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf

Package

List Price ($)

50 test

$ 319

Qty

HLA-A2 antibody [BB7.2] (PE)

Cat No. GTX75805

Host

Clonality

Clone Name

Isotype

Application

Reactivity