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HLA-B7 antibody [BB7.1] (FITC)

Anti-HLA-B7 antibody [BB7.1] (FITC) used in Flow cytometry (FACS). GTX76656

Cat No. GTX76656

Host

Mouse

Clonality

Monoclonal

Clone Name

BB7.1

Isotype

IgG1

Application

FACS

Reactivity

Human, Cynomolgus monkey
Package
100 μg ($339)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
FACS Neat-1/10

Note :

FACS
Use 10μl of the suggested working dilution to label 106 cells or 100μl whole blood.

Not tested in other applications.

Calculated MW

40 kDa. ( Note )

Specificity/Sensitivity

This antibody recognizes the HLA-B7 antigen and does not cross-react with HLA-B27 or other related antigens. It can be used to distinguish true HLA B27 positives from false HLA B27 positives (i.e. HLA B7 positive) in the investigation of diseases such as ankylosing spondylitis and anterior uveitis.

PROPERTIES

Form

Liquid

Buffer

PBS, 0.09% Sodium Azide, 1% BSA

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Protect from light.

Concentration

0.1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Papain solubilized HLA-B7 antigen

Purification

Protein A purified
From tissue culture supernatant

Conjugation

Fluorescein isothiocyanate (FITC)

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Major Histocompatibility Complex, Class I, B , As , B-4901 , Hlab , Hla-B

Background

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-HLA-B7 antibody [BB7.1] (FITC) used in Flow cytometry (FACS). GTX76656

GTX76656 FACS Image

FACS analysis of human peripheral blood lymphocytes using GTX76656 HLA-B7 antibody [BB7.1] (FITC).

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 339