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HLA-DR1 antibody [MEM-267]

Anti-HLA-DR1 antibody [MEM-267] used in Western Blot (WB). GTX78393

Cat. No. GTX78393

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 MEM-267

Isotype

 IgG2b

Application

 WB, FACS, ELISA

Reactivity

 Human
Package
100 μg ($399)
See all HLA-DR1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
FACS Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

30 kDa. ( Note )

Product Note

The antibody MEM-267 specifically binds to the empty but not peptide-loaded form of HLA-DR1.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified, insoluble DR1 beta chain (DRB1*0101) expressed in E. coli inclusion bodies.

Purification

Protein A purified

Conjugation

Unconjugated

RRID

AB_625639

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

DRB1 , HLADR1B , HLADRB , HLADRB1 , SS1 , major histocompatibility complex, class II, DR beta 1 , HLA Class II DRB1 , HLA-DRB1 , MHC Class II DRB1

Cellular Localization

Cell membrane,Endoplasmic reticulum membrane,Golgi apparatus,Trans-Golgi network membrane,Endosome membrane,Lysosome membrane,Late endosome membrane

Background

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-HLA-DR1 antibody [MEM-267] used in Western Blot (WB). GTX78393

GTX78393 WB Image

WB analysis of Raji (A) and Jurkat (B) cell lysates using GTX78393 HLA-DR1 antibody [MEM-267].

REFERENCE

Clone Reference

van der Vlist M et al. Eur J Immunol 2011; 41 (9):2619-31 Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4+ T cells but are incapable of cross-presentation.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399