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HMW Kininogen antibody [C11C1]

Anti-HMW Kininogen antibody [C11C1] used in Western Blot (WB). GTX21004

Cat. No. GTX21004

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 C11C1

Isotype

 IgG1

Application

 Coagulation assay, WB, ELISA

Reactivity

 Human
Package
50 μg ($399)
See all Kininogen 1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ELISA Assay dependent
Coagulation assay Assay dependent
Not tested in other applications.

Calculated MW

72 kDa. ( Note )

Product Note

This antibody recognizes an epitope on the unique 46kDa light chain of human HMWK. The epitope maps to domain 5 of human HMWK. It can completely neutralize the coagulant activity of human HMWK.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified human high molecular weight kininogen.

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

BDK , BK , KNG , KNG1 , kininogen 1

Cellular Localization

Secreted,Extracellular space

Background

This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2014]

Database

Research Area

DATA IMAGES

Anti-HMW Kininogen antibody [C11C1] used in Western Blot (WB). GTX21004

GTX21004 WB Image

WB analysis of (A) normal human plasma, (B) HMWK-deficient plasma, and (C) purified HMWK proteins using GTX21004 HMW Kininogen antibody [C11C1].

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399