HP1 gamma antibody [5G10-F7-A12]

Cat. No. GTX16488

Host	Mouse
Clonality	Monoclonal
Clone Name	5G10-F7-A12
Isotype	IgG1
Application	WB, ICC/IF, IHC-P, IP, Immunodiffusion
Reactivity	Human, Mouse, Rat, Hamster, Monkey
Package	100 μl ($399)

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Datasheet
Document

View product citations for antibody GTX16488 on CiteAb

APPLICATION

Calculated MW

21 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 0.5% BSA, 50% glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified recombinant human HP1-gamma protein fragments expressed in E.coli.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

chromobox 3 , HECH , HP1-GAMMA , HP1Hs-gamma

Cellular Localization

Nucleus

Background

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]

Database

Gene ID: 11335 CBX3
UniProt: Q13185 CBX3

Research Area

DATA IMAGES

GTX16488 IHC-P Image

IHC-P analysis of prostate cancer using HP1 gamma antibody [5G10-F7-A12] at a dilution of 1:200. Antigen retrieval was performed by pressure cooking in citrate buffer (pH 6.0).

GTX16488 ICC/IF Image

ICC/IF analysis of HeLa cells using HP1 gamma antibody [5G10-F7-A12] at a dilution of 1:200.

GTX16488 IP Image

IP analysis was performed with HeLa lysates and either control IgG PR HP1 gamma antibody [5G10-F7-A12]. The precipitates were detected by the same antibody.

GTX16488 WB Image

WB analysis of various cell lysates using HP1 gamma antibody [5G10-F7-A12] at a dilution of 1:1000.

REFERENCE

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf

Package

List Price ($)

100 μl

$ 399

Qty