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HP1 gamma antibody

Anti-HP1 gamma antibody used in Western Blot (WB). GTX00898
Anti-HP1 gamma antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX00898

Cat No. GTX00898

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF, ChIP assay

Reactivity

Human, Hamster
Package
50 μg ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:2000-1:10000
ICC/IF Assay dependent
ChIP assay Assay dependent
Not tested in other applications.

Calculated MW

21 kDa. ( Note )

Specificity/Sensitivity

chicken, Xenopus, Drosophila, and zebrafish

Predict Reactivity

Zebrafish, Drosophila, Chicken, Xenopus(>80% identity)

PROPERTIES

Form

Liquid

Buffer

Filter-sterilized 0.12 M sodium phosphate buffer (pH 7.4), 50% glycerol

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.75 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The product is prepared by immunizing rabbit with the synthetic peptide WHSCPEDEAQ-C corresponding to the C-terminal sequence of human HP1 gamma and purified by affinity purification with the peptide.

Purification

Purified IgG

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

chromobox 3 , CBX3 , HECH , HP1GAMMA , HP1Hsgamma , HP1 gamma

Cellular Localization

Nucleus

Background

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]

Database

Research Area

DATA IMAGES

Anti-HP1 gamma antibody used in Western Blot (WB). GTX00898

GTX00898 WB Image

WB analysis of BHK cell Lysate using GTX00898 HP1 gamma antibody.

Anti-HP1 gamma antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX00898

GTX00898 ICC/IF Image

ICC/IF analysis of BHK cells using GTX00898 HP1 gamma antibody.
Fixation : 4% PFA

REFERENCE

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REVIEW

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SDS
Glycerol.pdf
Package List Price ($)
$ 319