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HSD17B1 antibody

Anti-HSD17B1 antibody used in IHC (Paraffin sections) (IHC-P). GTX12312
Anti-HSD17B1 antibody used in IHC (Paraffin sections) (IHC-P). GTX12312
Anti-HSD17B1 antibody used in IHC (Paraffin sections) (IHC-P). GTX12312
Anti-HSD17B1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX12312
Anti-HSD17B1 antibody used in Western Blot (WB). GTX12312

Cat. No. GTX12312

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μg ($449)
See all HSD17B1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.1-0.5μg/ml
ICC/IF 0.5-1μg/ml
IHC-P 0.5-1μg/ml
Not tested in other applications.

Calculated MW

34.95 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.1% Na₂HPO₄, 0.45% NaCl, 2.5% BSA

Preservative

0.025% Thimerosal, 0.025% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

500 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human HSD17B1(29-43aa QSFKVYATLRDLKTQ), different from the related rat and mouse sequences by one amino acid.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Cellular Localization

Cytoplasm

Background

This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Database

Research Area

DATA IMAGES

Anti-HSD17B1 antibody used in IHC (Paraffin sections) (IHC-P). GTX12312

GTX12312 IHC-P Image

IHC-P analysis of human placenta tissue using GTX12312 HSD17B1 antibody.

Anti-HSD17B1 antibody used in IHC (Paraffin sections) (IHC-P). GTX12312

GTX12312 IHC-P Image

IHC-P analysis of rat ovary tissue using GTX12312 HSD17B1 antibody.

Anti-HSD17B1 antibody used in IHC (Paraffin sections) (IHC-P). GTX12312

GTX12312 IHC-P Image

IHC-P analysis of rat liver tissue using GTX12312 HSD17B1 antibody.

Anti-HSD17B1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX12312

GTX12312 ICC/IF Image

ICC/IF analysis of HeLa cell using GTX12312 HSD17B1 antibody.

Anti-HSD17B1 antibody used in Western Blot (WB). GTX12312

GTX12312 WB Image

WB analysis of various samples using GTX12312 HSD17B1 antibody.
Lane 1 : rat kidney tissue lysate
Lane 2 : rat liver tissue lysate
Lane 3 : 293T cell lysate
Lane 4 : HeLa cell lysate

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Thimerosal.pdf
Package List Price ($)
$ 449