APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Dilution |
| 1:500 - 1:2000 |
| 1:50 - 1:200 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS pH7.3, 50% Glycerol
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 803-1103 of human SETD2 (NP_054878.5).
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
SET domain containing 2, histone lysine methyltransferase , HBP231 , HIF-1 , HIP-1 , HSPC069 , HYPB , KMT3A , LLS , SET2 , p231HBP
Cellular Localization
Nucleus
Background
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]
Database
Research Area
DATA IMAGES
|
GTX64431 ICC/IF Image
ICC/IF analysis of U2OS cells using GTX64431 HYPB/SETD2 antibody.
Blue : DAPI
Dilution : 1:100
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GTX64431 WB Image
WB analysis of various sample lysates using GTX64431 HYPB/SETD2 antibody.
Dilution : 1:1000
Loading : 25μg per lane
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GTX64431 ICC/IF Image
ICC/IF analysis of C6 cells using GTX64431 HYPB/SETD2 antibody.
Blue : DAPI
Dilution : 1:100
|
REFERENCE
There are currently no references for HYPB/SETD2 antibody (GTX64431). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for HYPB/SETD2 antibody (GTX64431). Be the first to share your experience with this product.
