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Her2 / ErbB2 antibody [RM228]

Anti-Her2 / ErbB2 antibody [RM228] used in IHC (Paraffin sections) (IHC-P). GTX33616
Anti-Her2 / ErbB2 antibody [RM228] used in Western Blot (WB). GTX33616

Cat No. GTX33616

Host

Rabbit

Clonality

Monoclonal

Clone Name

RM228

Isotype

IgG

Application

WB, IHC-P

Reactivity

Human
Package
100 μl ($349)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:1000
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

138 kDa. ( Note )

Predict Reactivity

Mouse, Rat(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA, 0.09% sodium azide, 50% Glycerol

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A peptide corresponding to the C-terminus of Human c-erbB-2/HER-2

Purification

Protein A purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CD340,ERBB2,HER2,HER2/neu,MLN 19,NEU,NGL,TKR1,erbb2 receptor tyrosine kinase 2,Her2,ErbB2,Neu,EGFR2,erb-b2 receptor tyrosine kinase 2

Cellular Localization

Cell membrane,Cytoplasm,Perinuclear region,Nucleus

Background

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Her2 / ErbB2 antibody [RM228] used in IHC (Paraffin sections) (IHC-P). GTX33616

GTX33616 IHC-P Image

IHC-P analysis of human breast cancer tissue using GTX33616 Her2 / ErbB2 antibody [RM228].

Anti-Her2 / ErbB2 antibody [RM228] used in Western Blot (WB). GTX33616

GTX33616 WB Image

WB analysis of MCF-7, PC3, Jurkat, and A375 cell lysates using GTX33616 Her2 / ErbB2 antibody [RM228].

REFERENCE

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REVIEW

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Package List Price ($)
$ 349