Her2 / ErbB2 antibody [RM228]

Cat. No. GTX33616

Host	Rabbit
Clonality	Monoclonal
Clone Name	RM228
Isotype	IgG
Application	WB, IHC-P
Reactivity	Human
Package	100 μl ($399)

See all Her2 / ErbB2 products

Datasheet

View product citations for antibody GTX33616 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1:1000
IHC-P	1:100 - 1:400

Not tested in other applications.

Calculated MW

138 kDa. ( Note )

Predict Reactivity

Mouse, Rat(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA, 50% Glycerol

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A peptide corresponding to the C-terminus of Human c-erbB-2/HER-2

Purification

Protein A purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD340,ERBB2,HER2,HER2/neu,MLN 19,NEU,NGL,TKR1,erbb2 receptor tyrosine kinase 2,Her2,ErbB2,Neu,EGFR2,erb-b2 receptor tyrosine kinase 2

Cellular Localization

Cell membrane,Cytoplasm,Perinuclear region,Nucleus

Background

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

Database

Gene ID: 2064 ERBB2
UniProt: P04626 ERBB2

Research Area

DATA IMAGES

GTX33616 IHC-P Image

IHC-P analysis of human breast cancer tissue using GTX33616 Her2 / ErbB2 antibody [RM228].

GTX33616 WB Image

WB analysis of MCF-7, PC3, Jurkat, and A375 cell lysates using GTX33616 Her2 / ErbB2 antibody [RM228].

REFERENCE

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REVIEW

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Package

List Price ($)

100 μl

$ 399

Qty