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United States (US)

Her2 / ErbB2 peptide

Cat No. GTX22429

Application

IP

Species

Human
Package
500 μl ($179)

APPLICATION

Application Note

Blocking peptide for rabbit polyconal antibody to Her2 / ErbB2(GTX22428).

Calculated MW

138 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, BSA

Preservative

0.1% Sodium azide

Storage

Store this product at 4ºC, DO NOT FREEZE. The product is stable for one year from the date of shipment.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Region/Sequence

Peptide mapping to the carboxy terminus of human Neu (HER2 or ErbB-2).

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

erb-b2 receptor tyrosine kinase 2 , CD340 , HER-2 , HER-2/neu , HER2 , MLN 19 , NEU , NGL , TKR1

Cellular Localization

Nucleus

Background

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

There are currently no references for Her2 / ErbB2 peptide (GTX22429). Be the first to share your publications with this product.

REVIEW

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Package List Price ($)
$ 179