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Her4 / ErbB4 antibody

Anti-Her4 / ErbB4 antibody used in IHC (Paraffin sections) (IHC-P). GTX15137
Anti-Her4 / ErbB4 antibody used in Western Blot (WB). GTX15137

Cat. No. GTX15137

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse
Package
500 μl ($399)
See all Her4 / ErbB4 products

APPLICATION

Application Note

IHC-P: Use at a dilution of 1/50 for 10 min at RT. Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
WB: Use at an assay dependent dilution. Predicted molecular weight: 146.8 kDa.
Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

147 kDa. ( Note )

Positive Control

Breast carcinoma or skeletal muscle

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (Human) (C terminal).

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

erb-b2 receptor tyrosine kinase 4 , ALS19 , HER4 , p180erbB4

Cellular Localization

Cell membrane , Mitochondrion

Background

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Her4 / ErbB4 antibody used in IHC (Paraffin sections) (IHC-P). GTX15137

GTX15137 IHC-P Image

IHC-P analysis of human breast carcinoma using GTX15137 Her4 / ErbB4 antibody.

Anti-Her4 / ErbB4 antibody used in Western Blot (WB). GTX15137

GTX15137 WB Image

WB analysis of A431 cell lysate using GTX15137 Her4 / ErbB4 antibody.

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399