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Histamine H3 Receptor antibody

Anti-Histamine H3 Receptor antibody used in IHC (Frozen sections) (IHC-Fr). GTX04934
Anti-Histamine H3 Receptor antibody used in Western Blot (WB). GTX04934

Cat. No. GTX04934

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-Fr

Reactivity

 Mouse, Rat
Package
50 μl ($669)
See all Histamine H3 Receptor products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-Fr Assay dependent
Not tested in other applications.

Calculated MW

49 kDa. ( Note )

Product Note

This antibody was raised against rat HRH3 intracellular domain.

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

0.05% Sodium Azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.8 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Immunogen

Peptide (C)RTRLRLDGGREAGPE, corresponding to amino acids 228-242 of rat HRH3 (Q9QYN8). 3rd intracellular loop.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Cellular Localization

Cell membrane

Background

This gene encodes a histamine H3 receptor that belongs to the superfamily of G-protein coupled receptors. This protein functions as a presynaptic autoreceptor on histamine neurons in the brain, and a presynaptic heteroreceptor in nonhistamine-containing neurons in both the central and peripheral nervous systems. It is deemed a great target for the development of therapeutics for numerous disorders, including obesity, epilepsy, and such cognitive diseases as attention deficit hyperactivity disorder and Alzheimer's disease. Several alternatively spliced transcript variants encoding different isoforms, with different brain expression patterns and signaling properties, have been described for this gene. [provided by RefSeq, Jul 2012]

Database

Research Area

DATA IMAGES

Anti-Histamine H3 Receptor antibody used in IHC (Frozen sections) (IHC-Fr). GTX04934

GTX04934 IHC-Fr Image

IHC-Fr analysis of rat brain tissue using GTX04934 Histamine H3 Receptor antibody.
Green : primary antibody
Red : parvalbumin
Blue : DAPI
H3R is particularly expressed in dendrites of Purkinje cells (arrows).
Dilution : 1:100

Anti-Histamine H3 Receptor antibody used in Western Blot (WB). GTX04934

GTX04934 WB Image

WB analysis of various samples using GTX04934 Histamine H3 Receptor antibody prior incubated with (Lane 3-4) or without (Lane 1-2) blocking peptide.
Lane 1 and Lane 3 : rat brain tissue lysate
Lane 2 and lane 4 : mouse brain tissue lysate
Dilution : 1:200

REFERENCE

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Package List Price ($)
$ 669