0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 and 0.01% (w/v) Sodium Azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
1 mg/ml (Please refer to the vial label for the specific concentration.)
Histone H2AvD pS137 Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 132-141 of Drosophila melanogaster (fruit fly) H2AvD protein.
Affinity purified using phosphopeptide and cross-adsorbed against non-phosphorylated peptide
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Histone H2A variant , 5499 , CG5499 , Dmel\CG5499 , H2A , H2A.F/Z , H2A.V , H2A.X , H2A.Z , H2AV , H2AV_DROM , H2AX , H2AZ , H2Av , H2AvD , H2a.V , H2av , H2avD , HIS , HIS2AV , HIS2AVD , His , His2 , His2A , His2AV , His2AvD , HisH2Av , Hist , Hist2av , gamma-H2AV , gamma-H2Av , gamma-HIS2AV , gamma-His2Av , gammaH2AV , gammaH2Av , h2AvD , his , his2Av , l(3)05146 , l(3)810 , l(3)97Dd , l(3)L1602
Variant histones H2A are synthesized throughout the cell cycle and are very different from classical S-phase regulated H2A. H2AvD is vital for viability, but the exact function of variant histones H2A is not known. H2A is a core component of the nucleosome, an octamer containing two molecules each of H2A, H2B, H3 and H4. The octamer wraps approximately 146 bp of DNA. HsAvD is expressed both maternally and zygotically and is found in embryos through to adults (female only). The human homologue, H2AX, is phosphorylated by ATM protein kinase when double strand DNA breaks occur. In mouse, H2AX "knock out" mice have an increased incidence of cancer.