Lyophilized from 0.22 μm-filtered PBS (pH 7.4). Reconstitute with distilled water to a concentration of 0.1-0.5 mg/ml.
Store at -20ºC or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.
C-terminal 6×His and Avi tagged; Gln18-Ser740 of human ACE2 (Accession #Q9BYF1)
> 95 % by SDS-PAGE
< 0.1 EU/μg (determined by LAL method)
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
angiotensin I converting enzyme 2,ACE2,ACEH
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]