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Human ACE2 (ECD) protein, mouse IgG Fc tag (active)

Human ACE2 (ECD) protein, mouse IgG Fc tag (active). GTX135683-pro
Human ACE2 (ECD) protein, mouse IgG Fc tag (active). GTX135683-pro
Human ACE2 (ECD) protein, mouse IgG Fc tag (active). GTX135683-pro
Human ACE2 (ECD) protein, mouse IgG Fc tag (active). GTX135683-pro
Human ACE2 (ECD) protein, mouse IgG Fc tag (active). GTX135683-pro

Cat No. GTX135683-pro

Application

WB, ELISA, Functional Assay

Species

Human
Package
100 μg ($499)

APPLICATION

Calculated MW

92 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Storage

Store as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.

Region/Sequence

Human ACE2 of NP_068576.1 (Met1-Ser740) with the Fc region of mouse IgG1 at the C-terminus

Expression System

HEK293 cells

Purity

>90%

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

angiotensin I converting enzyme 2 , ACEH

Cellular Localization

Cytoplasm

Background

The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Human ACE2 (ECD) protein, mouse IgG Fc tag (active). GTX135683-pro

GTX135683-pro ELISA Image

Functional ELISA analysis of immobilized recombinant SARS-CoV-2 (COVID-19) Spike RBD protein, His tag (active) (GTX01546-pro) (coated at 2 μg/mL) binding to soluble recombinant Human ACE2 (ECD) protein , mouse IgG Fc tag (GTX135683-pro) (4.5-10000 ng/mL). Bound protein was detected by ACE2 antibody [N1N2], N-term (GTX101395) (0.5 μg/mL) and Rabbit IgG antibody (HRP) (GTX213110-01) (1:10000) detected bound primary antibody.

Human ACE2 (ECD) protein, mouse IgG Fc tag (active). GTX135683-pro

GTX135683-pro WB Image

GTX135683-pro Human ACE2 (ECD) protein , mouse IgG Fc tag protein (1 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with ACE2 antibody [N1N2], N-term (GTX101395) diluted at 1:100000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Human ACE2 (ECD) protein, mouse IgG Fc tag (active). GTX135683-pro

GTX135683-pro ELISA Image

Indirect ELISA analysis performed by coating plate with recombinant Human ACE2 (ECD) protein , mouse IgG Fc tag protein (GTX135683-pro) (15.63-1000 ng/mL). Coated protein probed with ACE2 antibody [N1N2], N-term (GTX101395) (0.1 μg/mL). Rabbit IgG antibody (HRP) (GTX213110-01) (1:10000) detected bound primary antibody.

Human ACE2 (ECD) protein, mouse IgG Fc tag (active). GTX135683-pro

GTX135683-pro ELISA Image

Inhibition analysis of immobilized recombinant SARS-CoV-2 (COVID-19) Spike S1 protein, His tag (active) (GTX01554-pro) (coated at 2 μg/mL) binding to soluble recombinant Human ACE2 (ECD) protein, mouse IgG Fc tag (GTX135683-pro) (1000 ng/mL). ACE2 binding was inhibited by increasing concentrations of SARS-CoV-2 (COVID-19) Spike RBD antibody (GTX135709) (14-10000 ng/mL). Bound ACE2 protein was detected by Goat Anti-Mouse IgG antibody (HRP) (GTX213111-01) (1:10000).

Human ACE2 (ECD) protein, mouse IgG Fc tag (active). GTX135683-pro

GTX135683-pro Functional Assay Image

Functional ELISA analysis of immobilized recombinant SARS-CoV-2 spike (trimer) (coated at 2 μg/mL) binding to soluble recombinant Human ACE2 (ECD) protein , mouse IgG Fc tag (GTX135683-pro) (14-10000 ng/mL). Bound protein was detected by Goat Anti-Mouse IgG antibody (HRP) (GTX213111-01) (1:10000).

REFERENCE

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REVIEW

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