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Human APP alpha (extracellular region) protein, His tag

Human APP alpha (extracellular region) protein, His tag. GTX02796-pro
Human APP alpha (extracellular region) protein, His tag. GTX02796-pro

Cat. No. GTX02796-pro

Species

 Human
Package
50 μg ($939)
See all APP protein products

APPLICATION

Observed MW

~100 kDa.

PROPERTIES

Form

Liquid

Buffer

PBS, 20% Glycerol

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (at least 1 month), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

batch dependent (Please refer to the vial label for the specific concentration.)

Region/Sequence

N-terminal 10 x His tagged ; 18-612 aa (Uniprot #P05067-4)

Expression System

HEK293 cells

Purity

> 95% by SDS-PAGE

Endotoxin

< 1 EU/弮g (Determined by LAL assay)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

amyloid beta precursor protein , AAA , ABETA , ABPP , AD1 , APPI , CTFgamma , CVAP , PN-II , PN2 , preA4

Cellular Localization

Cell membrane , Membrane , Cytoplasmic vesicle , Cytoplasm

Background

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]

Database

Research Area

DATA IMAGES

Human APP alpha (extracellular region) protein, His tag. GTX02796-pro

GTX02796-pro Image

WB analysis of GTX02796-pro Human APP alpha (extracellular region) protein and GTX02797-pro Human APP beta (extracellular region) protein using APP alpha specific antibody (clone[2B3]) (left panel) or APP beta specific antibody (clone [1A9]) (right panel).

Human APP alpha (extracellular region) protein, His tag. GTX02796-pro

GTX02796-pro Image

SDS-PAGE of GTX02796-pro Human APP alpha (extracellular region) protein.

REFERENCE

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REVIEW

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Package List Price ($)
$ 939