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Human Angiopoietin 2 protein, human IgG1 Fc tag

Human Angiopoietin 2 protein, human IgG1 Fc tag. GTX01250-pro
Human Angiopoietin 2 protein, human IgG1 Fc tag. GTX01250-pro

Cat No. GTX01250-pro

Application

Functional Assay

Species

Human
Package
50 μg ($359),
20 μg ($259)

APPLICATION

Application Note

Measured by its binding ability in a functional ELISA. Immobilized recombinant human Angiopoietin-2 protein at 10 μg/ml (100 μl/well) can bind Human Tie2 / Fc chimera protein with a range of 0.2-20 μg/ml.

Observed MW

110-115 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Batch dependent (please contact us for details)

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.

Region/Sequence

C-terminal human IgG1-Fc tagged; Met1-Phe496 of Human Angiopoietin 2 protein (NP_001138.1)

Expression System

HEK293 cells

Purity

> 95% by SDS-PAGE.

Endotoxin

< 1.0 EU/μg (determined by LAL method)

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

AGPT2,ANG2

Background

The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Human Angiopoietin 2 protein, human IgG1 Fc tag. GTX01250-pro

GTX01250-pro Functional Assay Image

The protein binding activity was measured in a functional ELISA analysis of Human Tie2 / Fc chimera protein which can bind immobilized GTX01250-pro Human Angiopoietin 2 protein.
Immobilized GTX01250-pro : 10 μg/ml (100 μl/well)
Human Tie2 / Fc chimera protein : 0.2-20 μg/ml

Human Angiopoietin 2 protein, human IgG1 Fc tag. GTX01250-pro

GTX01250-pro Image

SDS-PAGE of 5 μg GTX01250-pro Human Angiopoietin 2 protein.

REFERENCE

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REVIEW

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