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Human ApoE4 protein

Human ApoE4 protein. GTX136908-pro

Cat. No. GTX136908-pro

Species

 Human
Package
500 μg ($199)
See all ApoE4 protein products
PRODUCT

Summary

APOE belongs to the apolipoprotein family and is a 299 a.a. protein with three allelic variants that give rise to the APOE 2, APOE 3, and APOE 4 isoforms. APOE is directly involved in lipoprotein metabolism and functions as a ligand for multiple receptors (e.g., the LDL receptor). These isoforms are critical for brain homeostasis and, while APOE 2 was shown to be protective in terms of Alzheimer’s disease (AD) risk, the 34.4 kDa APOE 4 isoform is a major risk factor for late-onset AD.

APPLICATION

Observed MW

35 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Reconstitute with distilled water to 0.1 mg/ml. Lyophilized from 50mM PBS, 100mM NaCl, 5% Trehalose.

Preservative

No Preservative

Storage

Store at 4ºC or below. After reconstitution, keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. For long-term storage after reconstitution, aliquot and store at -70ºC or below. Do not vortex.

Region/Sequence

Full-length human ApoE4 protein (NP_000032.1)

Expression System

E. Coli

Purity

> 90%

Endotoxin

< 0.1 EU/μg

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

apolipoprotein E , AD2 , APO-E , ApoE4 , LDLCQ5 , LPG

Cellular Localization

Secreted,Secreted, extracellular space, extracellular matrix

Background

The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]

Database

Research Area

DATA IMAGES

Human ApoE4 protein. GTX136908-pro

GTX136908-pro Image

1μg of GTX136908-pro Human ApoE4 protein was analyzed using SDS-PAGE and stained with coomassie blue and captured by monochrome camera.

REFERENCE

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REVIEW

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Package List Price ($)
$ 199