APOE belongs to the apolipoprotein family and is a 299 a.a. protein with three allelic variants that give rise to the APOE 2, APOE 3, and APOE 4 isoforms. APOE is directly involved in lipoprotein metabolism and functions as a ligand for multiple receptors (e.g., the LDL receptor). These isoforms are critical for brain homeostasis and, while APOE 2 was shown to be protective in terms of Alzheimer’s disease (AD) risk, the 34.4 kDa APOE 4 isoform is a major risk factor for late-onset AD.
Reconstitute with sterile water to a concentration of 0.1 mg/ml. Do not vortex. Lyophilized from 50mM PBS (pH7.4), 100mM NaCl, 5% Trehalose.
Store at 4ºC or below. After reconstitution, keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Full-length human ApoE4 protein (NP_000032.1)
< 0.1 EU/μg
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
apolipoprotein E , AD2 , APO-E , ApoE4 , LDLCQ5 , LPG
Secreted,Secreted, extracellular space, extracellular matrix
The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
1μg of GTX136908-pro Human ApoE4 protein was analyzed using SDS-PAGE and stained with coomassie blue and captured by monochrome camera.