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Human BMP11 protein (active)

Cat No. GTX48322-pro

Application

Functional Assay

Species

Human
Package
20 μg ($319)
PRODUCT

Summary

Recombinant Human/Murine/Rat GDF-11 is a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. It is highly homologous to myostatin/GDF-8, sharing 90% amino acid sequence identity. Verified by N-terminal and Mass Spectrometry analyses (when applicable).

APPLICATION

Application Note

Assay #1 :The ED₅₀ was determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED₅₀ for this effect is 0.08-0.10 μg/ml.
Assay # 2 : Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1cells. The ED₅₀ for this effect is 8-10 ng/ml.

Specificity/Sensitivity

cross reactivity: Mouse

PROPERTIES

Form

Lyophilized powder

Buffer

Batch dependent (please contact us for details)

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Aliquot and avoid freeze-thaw cycles.

Region/Sequence

NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS

Expression System

E. coli

Purity

≥ 98% by SDS-PAGE and HPLC.

Endotoxin

< 1 EU/μg

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

growth differentiation factor 11 , BMP-11 , BMP11

Database

Research Area

REFERENCE

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REVIEW

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