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Human CD105 protein, human IgG1 Fc tag

Human CD105 protein, human IgG1 Fc tag. GTX01257-pro

Cat No. GTX01257-pro

Application

Functional Assay

Species

Human
Package
50 μg ($319),
20 μg ($219)

APPLICATION

Application Note

1. Measured by its ability to bind biotinylated Human TGFRB1 protein in a functional ELISA.
2. Measured by its ability to bind biotinylated Human ACVRL1 protein (active) (GTX01412-pro) in functional ELISA.

Observed MW

115-120 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Batch dependent (please contact us for details)

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.

Region/Sequence

C-terminal human IgG1-Fc tagged; Met1-Gly586 of Human CD105 protein (NP_001108225.1)

Expression System

HEK293 cells

Purity

> 95% by SDS-PAGE.

Endotoxin

< 1.0 EU/μg (determined by LAL method)

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

END,HHT1,ORW1

Background

This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]

Database

Research Area

DATA IMAGES

Human CD105 protein, human IgG1 Fc tag. GTX01257-pro

GTX01257-pro Image

SDS-PAGE of 5 μg GTX01257-pro Human CD105 protein.

REFERENCE

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REVIEW

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Package List Price ($)
$ 319
$ 219