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Human CD200 protein, mutant human IgG1 Fc tag (active)

Cat No. GTX65747-pro

Application

Functional Assay

Species

Human
Package
100 μg ($449)
PRODUCT

Summary

Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).

APPLICATION

Application Note

Shows the biological function of the CD200 moiety and exerts a prolonged circulating half- life caused by the modified Fc domain.

PROPERTIES

Form

Lyophilized powder

Buffer

Lyophilized from 0.2μm-filtered PBS. Reconstitute with 0.2μm-filtered PBS to 100 μg/ml.

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Aliquot and avoid freeze-thaw cycles.

Region/Sequence

The extracellular domain of human CD200 (a.a. 31-236) is fused to the N-terminus of the Fc region of a mutant human IgG1.

Expression System

CHO cells

Purity

≥ 98% by SDS-PAGE.

Endotoxin

< 0.06 EU/μg

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CD200 molecule , MOX1 , MOX2 , MRC , OX-2

Database

  • Gene ID: 4345 CD200

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 449