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Human CTLA4 protein, mutant human IgG1 Fc tag (active)

Cat No. GTX65744-pro

Application

Functional Assay

Species

Human
Package
100 μg ($219)
PRODUCT

Summary

Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).

APPLICATION

Application Note

Measured by its ability to inhibit IL-2 secretion by stimulated Jurkat human acute T cell leukemia cells.

PROPERTIES

Form

Lyophilized powder

Buffer

Reconstitute with 0.2μm-filtered PBS to 100μg/ml. Lyophilized from 0.2μm-filtered PBS.

Preservative

No preservative

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Aliquot and avoid freeze-thaw cycles.

Region/Sequence

The extracellular domain of human CD152 [CTLA-4] (a.a. 37-160) is fused to the N-terminus of the Fc region of a mutant human IgG1.

Expression System

CHO cells

Purity

≥ 98% by SDS-PAGE.

Endotoxin

< 0.06 EU/μg

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

cytotoxic T-lymphocyte associated protein 4 , ALPS5 , CD , CD152 , CELIAC3 , CTLA-4 , GRD4 , GSE , IDDM12

Database

  • Gene ID: 1493 CTLA4

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 219