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Human Cathepsin L protein, His tag

Human Cathepsin L protein, His tag. GTX01211-pro

Cat No. GTX01211-pro

Application

Functional Assay

Species

Human
Package
20 μg ($329),
10 μg ($249)

APPLICATION

Application Note

Measured by its binding ability in a functional ELISA. Immobilized human CD74 protein at 5 μg/ml (100 μl/well) can bind biotinylated human CTSL1 protein with a linear range of 3.2-400 ng/ml.

Observed MW

37 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Batch dependent (please contact us for details)

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.

Region/Sequence

C-terminal poly His tagged; Met1-Val333 of Human Cathepsin L protein (NP_001903.1)

Expression System

HEK293 cells

Purity

> 90% by SDS-PAGE.

Endotoxin

< 1.0 EU/μg (determined by LAL method)

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CATL,CTSL1,MEP

Background

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

Database

Research Area

DATA IMAGES

Human Cathepsin L protein, His tag. GTX01211-pro

GTX01211-pro Image

SDS-PAGE of 5 μg GTX01211-pro Human Cathepsin L protein.

REFERENCE

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Package List Price ($)
$ 329
$ 249