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Human FGFR1 alpha IIIc (extracellular region) protein, His tag

Human FGFR1 alpha IIIc (extracellular region) protein, His tag. GTX02782-pro

Cat. No. GTX02782-pro

Application

Functional Assay

Species

Human
Package
50 μg ($429)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
Functional Assay Assay dependent
Not tested in other applications.

Observed MW

~80 kDa.

PROPERTIES

Form

Liquid

Buffer

PBS, 20% Glycerol

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (at least 1 month), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

batch dependent (Please refer to the vial label for the specific concentration.)

Region/Sequence

C-terminal 10 x His tagged ; 22-375 aa (Uniprot #P11362-7)

Expression System

HEK293 cells

Purity

> 95% by SDS-PAGE

Endotoxin

< 0.1 ng/μg (1 IEU/μg) determined by LAL method

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

fibroblast growth factor receptor 1 , BFGFR , CD331 , CEK , ECCL , FGFBR , FGFR-1 , FLG , FLT-2 , FLT2 , HBGFR , HH2 , HRTFDS , KAL2 , N-SAM , OGD , bFGF-R-1

Cellular Localization

Cell membrane; Single-pass type I membrane protein , Nucleus , Cytoplasm, cytosol , Cytoplasmic vesicle

Background

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Human FGFR1 alpha IIIc (extracellular region) protein, His tag. GTX02782-pro

GTX02782-pro Image

SDS-PAGE of GTX02782-pro Human FGFR1 alpha IIIc (extracellular region) protein.

REFERENCE

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REVIEW

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Package List Price ($)
$ 429