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Human FGFR2 alpha IIIb (extracellular region) protein, His tag

Human FGFR2 alpha IIIb (extracellular region) protein, His tag. GTX02783-pro

Cat. No. GTX02783-pro

Species

 Human
Package
50 μg ($429)
See all FGFR2 protein products

APPLICATION

Observed MW

~80 kDa.

PROPERTIES

Form

Liquid

Buffer

PBS, 20% Glycerol

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (at least 1 month), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

batch dependent (Please refer to the vial label for the specific concentration.)

Region/Sequence

C-terminal 10 x His tagged ; 22-378 aa (Uniprot #P21802-3)

Expression System

HEK293 cells

Purity

> 95% by SDS-PAGE

Endotoxin

< 1 EU/弮g (Determined by LAL assay)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

fibroblast growth factor receptor 2 , BBDS , BEK , BFR-1 , CD332 , CEK3 , CFD1 , ECT1 , JWS , K-SAM , KGFR , TK14 , TK25

Cellular Localization

Cell membrane; Single-pass type I membrane protein , Golgi apparatus , Cytoplasmic vesicle

Background

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

Database

Research Area

DATA IMAGES

Human FGFR2 alpha IIIb (extracellular region) protein, His tag. GTX02783-pro

GTX02783-pro Image

SDS-PAGE of GTX02783-pro Human FGFR2 alpha IIIb (extracellular region) protein.

REFERENCE

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Package List Price ($)
$ 429