APPLICATION
PROPERTIES
Form
Liquid
Buffer
PBS, 20% Glycerol
Preservative
No preservative
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (at least 1 month), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
batch dependent (Please refer to the vial label for the specific concentration.)
Region/Sequence
C-terminal 10 x His tagged ; 22-369 aa (Uniprot #P22455)
Expression System
HEK293 cells
Purity
> 95% by SDS-PAGE
Endotoxin
< 1 EU/弮g (Determined by LAL assay)
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
fibroblast growth factor receptor 4 , CD334 , JTK2 , TKF
Cellular Localization
Cell membrane; Single-pass type I membrane protein , Endosome , Endoplasmic reticulum
Background
The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017]
Database
Research Area
DATA IMAGES
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GTX02787-pro Image
SDS-PAGE of GTX02787-pro Human FGFR4 (extracellular region) protein.
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REFERENCE
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REVIEW
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