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Human Folate Receptor beta protein, His tag

Human Folate Receptor beta protein, His tag. GTX02865-pro
Human Folate Receptor beta protein, His tag. GTX02865-pro

Cat. No. GTX02865-pro

Application

 Functional Assay

Species

 Human
Package
50 μg ($379)
See all Folate Receptor beta products

APPLICATION

Application Note

Binding assay: Measured by its binding ability in a functional ELISA with Folic Acid-BSA. The ED₅₀ range ≤ 5 μg/ml.

Calculated MW

29 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 10% Glycerol

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1 week), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.25 mg/ml (Please refer to the vial label for the specific concentration.)

Region/Sequence

His-Tagged; 22-230aa (P14207, NP_000794.3)

Expression System

HEK293 cells

Purity

> 90% by SDS-PAGE

Endotoxin

< 1.0 EU/μg (determined by LAL method)

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

folate receptor beta , BETA-HFR , FBP , FBP/PL-1 , FR-BETA , FR-P3

Background

The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Human Folate Receptor beta protein, His tag. GTX02865-pro

GTX02865-pro Image

SDS-PAGE analysis of 3μg GTX02865-pro Human Folate Receptor beta protein under reducing condition.

Human Folate Receptor beta protein, His tag. GTX02865-pro

GTX02865-pro Functional Assay Image

The protein binding activity was measured in a functional ELISA analysis of GTX02865-pro Human Folate Receptor beta protein which can bind immobilized Folic Acid-BSA.
Immobilized recombinant Folic Acid-BSA : 10 μg/ml (100 μl/well)
GTX02865-pro : ≤ 5 μg/ml

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Package List Price ($)
$ 379