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Human HEXA protein, His tag (active)

Human HEXA protein, His tag (active). GTX03538-pro

Cat. No. GTX03538-pro

Application

 Functional Assay

Species

 Human
Package
50 μg ($399)
See all HEXA protein products

APPLICATION

Application Note

Measured by its ability to hydrolyze 4-methylumbelliferyl-N-acetyl-β-D-glucosaminide (4-MU-Glc-NAc). The specific activity is > 1,250 pmoles/min/μg.

Observed MW

64 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Batch dependent (please contact us for details)

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.

Region/Sequence

C-terminal polyhistidine tag; Met 1-Thr 529 (AAD13932.1)

Expression System

Baculovirus-Insect Cells

Purity

> 95 % by SDS-PAGE.

Endotoxin

< 1.0 EU/μg (determined by LAL method)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

hexosaminidase subunit alpha , TSD

Cellular Localization

Lysosome

Background

This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

Database

Research Area

DATA IMAGES

Human HEXA protein, His tag (active). GTX03538-pro

GTX03538-pro Image

SDS-PAGE of GTX03538-pro human HEXA protein, His tag (active).

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Package List Price ($)
$ 399