GeneTex

  • Country / Location Selection

United States (US)

Human HEXB protein, His tag (active)

Human HEXB protein, His tag (active). GTX03539-pro

Cat. No. GTX03539-pro

Application

 Functional Assay

Species

 Human
Package
100 μg ($369)
See all HEXB protein products

APPLICATION

Application Note

Measured by its ability to hydrolyze 4methylumbelliferylNacetylβDglucosaminide(4MUGlcNAc). The specific activity is > 3000 pmols/min/μg

Observed MW

60-66 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Batch dependent (please contact us for details)

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.

Region/Sequence

C-terminal polyhistidine tag; Ala43-Met556 (P07686)

Expression System

HEK293 Cells

Purity

> 95 % by SDS-PAGE.

Endotoxin

< 1.0 EU/μg (determined by LAL method)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

hexosaminidase subunit beta , ENC-1AS , HEL-248 , HEL-S-111

Cellular Localization

Lysosome

Background

Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Database

Research Area

DATA IMAGES

Human HEXB protein, His tag (active). GTX03539-pro

GTX03539-pro Image

SDS-PAGE of GTX03539-pro human HEXB protein, His tag (active).

REFERENCE

There are currently no references for Human HEXB protein, His tag (active) (GTX03539-pro). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for Human HEXB protein, His tag (active) (GTX03539-pro). Be the first to share your experience with this product.
Submit a Review
Package List Price ($)
$ 369