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Human ICOS Ligand protein, mutant human IgG1 Fc tag (active)

Cat. No. GTX65746-pro

Application

 Functional Assay

Species

 Human
Package
100 μg ($429)
See all ICOS Ligand protein products
PRODUCT

Summary

Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).

APPLICATION

Application Note

Measured by its ability to stimulate human T cell proliferation in the presence of anti-CD3.

PROPERTIES

Form

Lyophilized powder

Buffer

Reconstitute with 100 μl ddH₂O. Lyophilized from 0.2μm-filtered PBS.

Preservative

No preservative

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Aliquot and avoid freeze-thaw cycles.

Region/Sequence

The extracellular domain of human CD275 [B7-H2] (a.a. 1-256) is fused to the N-terminus of the Fc region of a mutant human IgG1.

Expression System

CHO cells

Purity

??98% by SDS-PAGE.

Endotoxin

< 0.06 EU/μg

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

inducible T cell costimulator ligand , B7-H2 , B7H2 , B7RP-1 , B7RP1 , CD275 , GL50 , ICOS-L , ICOSL , LICOS

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 429