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Human IL22 (ECD) protein, human IgG1 Fc tag (non-lytic) (active)

Cat. No. GTX03263-pro

Application

 Functional Assay

Species

 Human
Package
50 μg ($489)
See all IL22 products

APPLICATION

Application Note

Functional assay: Shows the biological function of the IL-22 moiety and exerts a prolonged circulating half-life caused by the modified (Non-lytic) Fc domain. Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).

Observed MW

46 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Reconstitute with 50 μg vial in 50 μl sterile water. Add 1x PBS to the desired protein concentration. Lyophilized from 0.2μm-filtered solution in PBS.

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Region/Sequence

The extracellular domain of human IL-22 (aa 34-179) is fused to the N-terminus of the Fc region of a mutant human IgG1.

Expression System

CHO Cells

Purity

> 95% by SDS-PAGE

Endotoxin

<1.0 EU per mg (determined by the LAL method)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

interleukin 22 , IL-21 , IL-22 , IL-D110 , IL-TIF , ILTIF , TIFIL-23 , TIFa , zcyto18

Cellular Localization

Secreted

Background

This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. [provided by RefSeq, Jul 2018]

Database

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 489