GeneTex

  • Country / Location Selection

United States (US)

Human K-Ras (G12V mutant) protein, His tag

Human K-Ras (G12V mutant) protein, His tag. GTX04508-pro

Cat. No. GTX04508-pro

Species

 Human
Package
50 μg ($409)
See all K-Ras protein products

APPLICATION

Observed MW

27 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Reconstitute to a concentration less than 0.1 mg/ml. Lyophilized from a 0.2 μm filtered PBS (pH 7.4).

Preservative

No preservatives

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Region/Sequence

N-terminal His tagged full length human KRAS protein (Thr2-Cys185, with natural variant Gly12Val), Uniprot #P01116-2)

Expression System

E. coli

Purity

>95% by SDS-PAGE

Endotoxin

<1.0 EU/1μg

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

KRAS proto-oncogene, GTPase , C-K-RAS , CFC2 , K-RAS2A , K-RAS2B , K-RAS4A , K-RAS4B , K-Ras , KI-RAS , KRAS1 , KRAS2 , NS , NS3 , RALD , RASK2 , c-Ki-ras2

Cellular Localization

Cell membrane , Cytoplasm, cytosol

Background

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Human K-Ras (G12V mutant) protein, His tag. GTX04508-pro

GTX04508-pro Image

SDS-PAGE analysis of GTX04508-pro Human K-Ras (G12V mutant) protein, His tag under reducing conditions.

REFERENCE

There are currently no references for Human K-Ras (G12V mutant) protein, His tag (GTX04508-pro). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for Human K-Ras (G12V mutant) protein, His tag (GTX04508-pro). Be the first to share your experience with this product.
Submit a Review
Package List Price ($)
$ 409