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Human LAG3 protein, human IgG1 Fc tag (active)

Human LAG3 protein, human IgG1 Fc tag (active). GTX65640-pro
Human LAG3 protein, human IgG1 Fc tag (active). GTX65640-pro

Cat No. GTX65640-pro

Application

Functional Assay

Species

Human
Package
50 μg ($389)

APPLICATION

Application Note

Inhibits binding of MAb to LAG-3 (human) to LAG-3. Induces maturation of human dendritic cells.

Product Note

Binds to human, mouse and monkey MHC class II.

PROPERTIES

Form

Liquid

Buffer

PBS.

Storage

Store as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Region/Sequence

Thecoding for the 4 extracellular Ig-like domains of human LAG-3 (D1-D4) is fused to the Fc portion of human IgG1.

Expression System

CHO cells

Purity

≥ 99% by SDS-PAGE.

Endotoxin

< 0.001 EU/μg

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

lymphocyte activating 3 , CD223

Database

  • Gene ID: 3902 LAG3

Research Area

DATA IMAGES

Human LAG3 protein, human IgG1 Fc tag (active). GTX65640-pro

GTX65640-pro Image

LAG3 human Fc fusion protein (GTX65640-pro) induced dendritic cells (DC) maturation. Method: Immature DCs derived from human monocytes, resuspended at 1x106 cells/ml in complete culture medium, are incubated with LAG3 human Fc fusion protein (GTX65640)(10μg/ml), LPS (positive control, 5μg/ml) or human IgG1 (isotype-matched negative control, 10μg/ml) for 48 hours. DC maturation induced by LAG3 human Fc fusion protein or LPS is assessed by the increased expression of MHC Class II, CD80, CD83, CD86 and CD40.

Human LAG3 protein, human IgG1 Fc tag (active). GTX65640-pro

GTX65640-pro Image

Binding of LAG3 human Fc fusion protein (GTX65640-pro) on dendritic and B cells. Method: Monocyte-derived immature DC (iDC), DC matured for 48h with LPS (mDC) and EBV-transformed B-cells are incubated with either an anti-MHC class II MAb (10μg/ml) or GTX65640 LAG3 human Fc fusion protein (10μg/ml) for 30 min. at 4ºC in PBS/1% BSA. The cells are then stained for 30 min. at 4ºC with anti-human Fc antibody.

REFERENCE

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REVIEW

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SDS
PBS.pdf