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Human LIFR protein, His tag

Human LIFR protein, His tag. GTX01365-pro
Human LIFR protein, His tag. GTX01365-pro

Cat. No. GTX01365-pro

Application

Functional Assay

Species

Human
Package
100 μg ($349)

APPLICATION

Application Note

1. Measured by its ability to bind Human LIF protein (active) (GTX01275-pro) in a functional ELISA.
2. Measured by its binding ability in a functional ELISA. Immobilized Human Oncostatin M protein (active) (GTX01278-pro) at 10 μg/ml (100 μl/well) can bind biotinylated Human LIFR protein (active) (GTX01365-pro) with a linear range of 0.031-0.5 μg/ml.

Observed MW

125-135 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Batch dependent (please contact us for details)

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.

Region/Sequence

C-terminal poly His tagged; Met1-Ser833 of Human LIFR protein (NP_001121143.1)

Expression System

HEK293 cells

Purity

> 90% by SDS-PAGE.

Endotoxin

< 1.0 EU/μg (determined by LAL method)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD118,LIF-R,SJS2,STWS,SWS

Background

This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2018]

Database

Research Area

DATA IMAGES

Human LIFR protein, His tag. GTX01365-pro

GTX01365-pro Functional Assay Image

The protein binding activity was measured in a functional ELISA analysis of GTX01275-pro Human LIF protein which can bind immobilized GTX01365-pro Human LIFR protein.
ED₅₀ : 3-12 ng/ml

Human LIFR protein, His tag. GTX01365-pro

GTX01365-pro Image

SDS-PAGE of 5 μg GTX01365-pro Human LIFR protein.

REFERENCE

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REVIEW

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Package List Price ($)
$ 349