50 mM Tris (pH 8.0), 100 mM NaCl, 0.5 mM GSH, 0.1 mM EGTA, 0.1 mM EDTA, 0.5 mM PMSF, 10% glycerol.
Store as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Batch dependent (Please refer to the vial label for the specific concentration.)
N-terminal GST tagged; Met1-Pro509 of Human Lck protein (NP_001036236.1)
Baculovirus (Insect cells)
> 90% by SDS-PAGE.
< 1.0 EU/μg (determined by LAL method)
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016]