Form
Lyophilized powder
Buffer
Reconstitute in 20mM Tris, 150mM NaCl pH8.0 to a concentration of 0.1-1.0 mg/mL. Do not vortex. Lyophilized from 20mM Tris, 150mM NaCl pH8.0, 0.01% SKL, 5% Trehalose.
Preservative
No preservatives
Storage
Store at -20ºC or below. After reconstitution, keep as concentrated solution. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Region/Sequence
N-terminal His tagged full length human Lipocalin-2 protein (Gln21~Gly198: a signal peptide removed), Uniprot #P80188-1).
Expression System
293F cell
Purity
>90% by SDS-PAGE
Endotoxin
<1.0 EU/1μg
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Synonyms
lipocalin 2 , 24p3 , MSFI , NGAL , p25
Cellular Localization
Secreted
Background
This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015]
Database
Research Area