GeneTex
United States (US)

Human M-CSF protein (active)

Cat No. GTX29694-pro

Species Human
PRODUCT

Product Description

Macrophage Colony Stimulating Factor Human Recombinant produced in E.coli is a disulfide linked homodimer, non-glycosylated, polypeptide chain containing 2 x 159 amino acids and having a total molecular mass of 36.8 KD.
APPLICATION

Application Note

The ED₅₀, calculated by the dose-dependent stimulation of the proliferation of murine M-NFS-60 indicator cells was found to be < 1.4-2.1 ng/ml.

Calculated MW

60.18 kDa. ( Note )
PROPERTIES

Form

Lyophilized powder

Buffer

Lyophilized from 10 mM Sodium Phosphate (pH 8.0), 50 mM NaCl. Reconstitute with ddH₂O to 0.1 mg/ml.

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Aliquot and avoid freeze-thaw cycles.

Region/Sequence

MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS.

Expression System

E. coli

Purity

> 97% by SDS-PAGE and HPLC.

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

colony stimulating factor 1 , CSF-1 , MCSF

Background

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Database

Research Area

Package List Price ($)
$ 299