APPLICATION
Application Note
Measured by its ability to cleave the fluorogenic peptide substrate, McaPLGL-Dpa-AR-NH2. The specific activity is > 400 pmoles/min/μg.
Note: The proenzyme needs to be activated by APMA for an activated form.
Observed MW
50-55 kDa.
PROPERTIES
Form
Lyophilized powder
Buffer
Batch dependent (please contact us for details)
Storage
Store at -20ºC or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.
Region/Sequence
C-terminal poly His tagged; Met1-Asn469 of Human MMP1 protein (NP_002412.1)
Expression System
HEK293 cells
Purity
> 96% by SDS-PAGE.
Endotoxin
< 1.0 EU/μg (determined by LAL method)
Conjugation
Unconjugated
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
CLG,CLGN
Background
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Database
Research Area
DATA IMAGES
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GTX01217-pro Image
SDS-PAGE of 5 μg GTX01217-pro Human MMP1 protein, His tag (active).
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REFERENCE
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REVIEW
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