Human MMP1 protein, His tag (active)

Cat No. GTX01217-pro

Application	Functional Assay
Species	Human
Package	20 μg ($339), 10 μg ($259)

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Datasheet

APPLICATION

Application Note

Measured by its ability to cleave the fluorogenic peptide substrate, McaPLGL-Dpa-AR-NH2. The specific activity is > 400 pmoles/min/μg.
Note: The proenzyme needs to be activated by APMA for an activated form.

Observed MW

50-55 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Batch dependent (please contact us for details)

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.

Region/Sequence

C-terminal poly His tagged; Met1-Asn469 of Human MMP1 protein (NP_002412.1)

Expression System

HEK293 cells

Purity

> 96% by SDS-PAGE.

Endotoxin

< 1.0 EU/μg (determined by LAL method)

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CLG,CLGN

Background

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Database

Gene ID: 4312 MMP1
UniProt: P03956 MMP1

Research Area

DATA IMAGES

GTX01217-pro Image

SDS-PAGE of 5 μg GTX01217-pro Human MMP1 protein, His tag (active).

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Package

List Price ($)

20 μg

$ 339

10 μg

$ 259

Qty