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United States (US)

Human MMP7 protein (Active)

Cat. No. GTX02553-pro

Application

 Functional Assay

Species

 Human
Package
20 μg ($299)
See all MMP7 protein products

APPLICATION

Application Note

The specific activity was found to be 6,200 U/mg. One unit is defined as the digestion of 1 μg Azocoll/min at 37ºC.

Calculated MW

30 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM HEPES (pH7.4), 5mM CaCl₂, 150mM NaCl

Preservative

No preservative

Storage

Store as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.

Expression System

E. coli

Purification

Purified by proprietary chromatographic techniques

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

matrix metallopeptidase 7 , MMP-7 , MPSL1 , PUMP-1

Background

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]

Database

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 299