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Human MMP8 protein, His tag (active)

Human MMP8 protein, His tag (active). GTX01218-pro

Cat No. GTX01218-pro

Application

Functional Assay

Species

Human
Package
20 μg ($329),
10 μg ($249)

APPLICATION

Application Note

Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2.The specific activity is > 250 pmoles/min/μg.
Note: The proenzyme needs to be activated by APMA for an activated form.

Observed MW

65-75 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Batch dependent (please contact us for details)

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.

Region/Sequence

C-terminal poly His tagged; Met1-Gly467 of Human MMP8 protein (NP_002415.1)

Expression System

HEK293 cells

Purity

> 90% by SDS-PAGE.

Endotoxin

< 1.0 EU/μg (determined by LAL method)

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CLG1,HNC,MMP-8,PMNL-CL

Background

This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Database

Research Area

DATA IMAGES

Human MMP8 protein, His tag (active). GTX01218-pro

GTX01218-pro Image

SDS-PAGE of 5 μg GTX01218-pro Human MMP8 protein, His tag (active).

REFERENCE

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REVIEW

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